Humans May Soon Regrow Lost Teeth! | The Future of Dentistry
For centuries, losing an adult tooth meant relying on dentures, implants, or bridges. But now, scientists are on the verge of making something once thought impossible a reality: the ability for humans to regrow lost teeth naturally.
Groundbreaking research in Japan is leading the way, and experts predict that a tooth-regrowth drug could be available by 2030.
The Science Behind Tooth Regrowth
Researchers at Kyoto University Hospital have developed a drug that works by targeting a protein called USAG-1, which suppresses tooth growth. By blocking this protein, dormant tooth-forming buds can be reactivated—essentially allowing the body to grow new teeth.
Animal studies in mice and ferrets showed promising results, with subjects successfully regrowing lost teeth. Encouraged by these outcomes, researchers began the first human clinical trials in September 2024.
The initial trial includes 30 men aged 30–64 who are each missing at least one molar. So far, the drug has shown no serious side effects in animal testing, and if successful, it could move on to children with congenital tooth absence.
Why This Breakthrough Matters
Tooth loss affects millions worldwide due to decay, gum disease, injury, or aging. Current treatments like implants and dentures are effective but come with challenges such as:
High cost and accessibility issues
Risk of infection or rejection
Lack of natural tooth function and sensation
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